Human Anti-MS4A1 Recombinant Antibody (clone 2F2) (CAT#: PABL-422)
Recombinant Human Antibody (2F2) is capable of binding to CD20, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-CD20 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-CD20 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody is a fully human anti-CD20 antibody that is currently in phase III clinical trial for several types of malignancies and autoimmune diseases and is one of the most promising antiCD20 drugs.
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Figure 1 Western blot analysis of purified anti-CD20 mAbs separated by SDS-PAGE.
Lane1, molecular weight protein markers; lane2, C2B8; lane3, 2F2; lane4, C2B8(ScFvHL)4-Fc; lane5, 2F2(ScFvHL)4-Fc.
Li, B., Shi, S., Qian, W., Zhao, L., Zhang, D., Hou, S., ... & Guo, Y. (2008). Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity. Cancer research, 68(7), 2400-2408.
Specifications
- Immunogen
- Human membrane-spanning 4-domains, subfamily A, member 1
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG1,κ
- Specificity
- CD20
- Species Reactivity
- Human
- Clone
- 2F2
- Applications
- WB, ELISA, FuncS
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1;
- Gene ID
- 931
- UniProt ID
- P11836
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-207 | Anti-Human CD20 Recombinant Antibody | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
| TAB-1633CL | Anti-Human MS4A1 Recombinant Antibody (ch1F5) | FC, Apop, CDC, ADCC, Inhib | Chimeric antibody (mouse/human) |
| TAB-1634CL | Anti-Human MS4A1 Recombinant Antibody (ch1F5-DXL) | FC, Apop, CDC, ADCC, Inhib | Chimeric antibody (mouse/human) |
| TAB-1656CL | Anti-Human MS4A1 Recombinant Antibody (ch2B8) | FC, CMCD, ADCC, Activ, Inhib, Depletion | Chimeric antibody (mouse/human) |
| PABX-026 | Recombinant Human Anti-CD20 Antibody (C2H7) | FuncS | IgG |
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# PABL-422, RRID: AB_3111657)
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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